The effect of liver enzymes on adiposity: a Mendelian randomization study.

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dc.citation.issue1
dc.citation.volume9
dc.contributor.authorLiu J
dc.contributor.authorAu Yeung SL
dc.contributor.authorKwok MK
dc.contributor.authorLeung JYY
dc.contributor.authorLin SL
dc.contributor.authorHui LL
dc.contributor.authorLeung GM
dc.contributor.authorSchooling CM
dc.coverage.spatialEngland
dc.date.accessioned2024-10-02T00:44:34Z
dc.date.available2024-10-02T00:44:34Z
dc.date.issued2019-11-14
dc.description.abstractPoorer liver function is positively associated with diabetes in Mendelian randomization (MR) studies. Observationally, adiposity is associated with poorer liver function. To clarify the etiology, we assessed the association of liver enzymes with adiposity observationally and using two-sample MR for validation. In the "Children of 1997" birth cohort, we used multivariable linear regression to assess the associations of alanine transaminase (ALT) and alkaline phosphatase (ALP) at ~17.5 years with body mass index (BMI) (n = 3,458). Using MR, genetic predictors of ALT, ALP and gamma glutamyltransferase (GGT), were applied to genome-wide association studies of BMI (n = 681,275), waist circumference (WC) (n = 224,459) and waist-hip ratio (WHR) (n = 224,459) to obtain unconfounded estimates. Observationally, ALT was positively associated with BMI (0.10 kg/m2 per IU/L, 95% confidence interval (CI) 0.09 to 0.11). ALP was inversely associated with BMI (-0.018 kg/m2 per IU/L, 95% CI -0.024 to -0.012). Using MR, ALT was inversely associated with BMI (-0.14 standard deviation per 100% change in concentration, 95% CI -0.20 to -0.07), but not WC or WHR. ALP and GGT were unrelated to adiposity. Poorer liver function might not cause adiposity; instead higher ALT might reduce BMI, raising the question as to the role of ALT in body composition.
dc.description.confidentialfalse
dc.format.pagination16792-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31727910
dc.identifier.citationLiu J, Au Yeung SL, Kwok MK, Leung JYY, Lin SL, Hui LL, Leung GM, Schooling CM. (2019). The effect of liver enzymes on adiposity: a Mendelian randomization study.. Sci Rep. 9. 1. (pp. 16792-).
dc.identifier.doi10.1038/s41598-019-52489-8
dc.identifier.eissn2045-2322
dc.identifier.elements-typejournal-article
dc.identifier.issn2045-2322
dc.identifier.number16792
dc.identifier.pii10.1038/s41598-019-52489-8
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71562
dc.languageeng
dc.publisherSpringer Nature Limited
dc.publisher.urihttps://www.nature.com/articles/s41598-019-52489-8
dc.relation.isPartOfSci Rep
dc.rights(c) 2019 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdiposity
dc.subjectAdolescent
dc.subjectAlanine Transaminase
dc.subjectAlkaline Phosphatase
dc.subjectBody Mass Index
dc.subjectFemale
dc.subjectGenome-Wide Association Study
dc.subjectHumans
dc.subjectLinear Models
dc.subjectLiver
dc.subjectMale
dc.subjectMendelian Randomization Analysis
dc.subjectPolymorphism, Single Nucleotide
dc.subjectgamma-Glutamyltransferase
dc.titleThe effect of liver enzymes on adiposity: a Mendelian randomization study.
dc.typeJournal article
pubs.elements-id491216
pubs.organisational-groupCollege of Health
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