Genomic Analysis of Salmonella enterica Serovar Typhimurium DT160 Associated with a 14-Year Outbreak, New Zealand, 1998-2012.

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dc.citation.issue6
dc.citation.volume23
dc.contributor.authorBloomfield SJ
dc.contributor.authorBenschop J
dc.contributor.authorBiggs PJ
dc.contributor.authorMarshall JC
dc.contributor.authorHayman DTS
dc.contributor.authorCarter PE
dc.contributor.authorMidwinter AC
dc.contributor.authorMather AE
dc.contributor.authorFrench NP
dc.date.available2017-06
dc.date.issued2017-06
dc.description.abstractDuring 1998-2012, an extended outbreak of Salmonella enterica serovar Typhimurium definitive type 160 (DT160) affected >3,000 humans and killed wild birds in New Zealand. However, the relationship between DT160 within these 2 host groups and the origin of the outbreak are unknown. Whole-genome sequencing was used to compare 109 Salmonella Typhimurium DT160 isolates from sources throughout New Zealand. We provide evidence that DT160 was introduced into New Zealand around 1997 and rapidly propagated throughout the country, becoming more genetically diverse over time. The genetic heterogeneity was evenly distributed across multiple predicted functional protein groups, and we found no evidence of host group differentiation between isolates collected from human, poultry, bovid, and wild bird sources, indicating ongoing transmission between these host groups. Our findings demonstrate how a comparative genomic approach can be used to gain insight into outbreaks, disease transmission, and the evolution of a multihost pathogen after a probable point-source introduction.
dc.description.publication-statusPublished
dc.format.extent906 - 913
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000402259100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationEMERGING INFECTIOUS DISEASES, 2017, 23 (6), pp. 906 - 913
dc.identifier.doi10.3201/eid2306.161934
dc.identifier.eissn1080-6059
dc.identifier.elements-id354060
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1080-6040
dc.identifier.urihttps://hdl.handle.net/10179/11351
dc.relation.isPartOfEMERGING INFECTIOUS DISEASES
dc.relation.urihttps://wwwnc.cdc.gov/eid/article/23/6/16-1934_article
dc.subject.anzsrc1103 Clinical Sciences
dc.subject.anzsrc1108 Medical Microbiology
dc.subject.anzsrc1117 Public Health and Health Services
dc.titleGenomic Analysis of Salmonella enterica Serovar Typhimurium DT160 Associated with a 14-Year Outbreak, New Zealand, 1998-2012.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Mathematical and Computational Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Natural Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
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