Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients.

Simple item page
dc.citation.issue3
dc.citation.volume9
dc.contributor.authorPalmer BR
dc.contributor.authorSlow S
dc.contributor.authorEllis KL
dc.contributor.authorPilbrow AP
dc.contributor.authorSkelton L
dc.contributor.authorFrampton CM
dc.contributor.authorPalmer SC
dc.contributor.authorTroughton RW
dc.contributor.authorYandle TG
dc.contributor.authorDoughty RN
dc.contributor.authorWhalley GA
dc.contributor.authorLever M
dc.contributor.authorGeorge PM
dc.contributor.authorChambers ST
dc.contributor.authorEllis C
dc.contributor.authorRichards AM
dc.contributor.authorCameron VA
dc.date.available2014-03-11
dc.date.available2014-01-19
dc.date.issued2014
dc.description.abstractBACKGROUND AND AIMS: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism. Polymorphisms in MTHFD1L, including rs6922269, have been implicated in risk for coronary artery disease (CAD). We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart disease patients. METHODS AND RESULTS: DNA and plasma from 1940 patients with acute coronary syndromes were collected a median of 32 days after index hospital admission (Coronary Disease Cohort Study, CDCS). Samples from a validation cohort of 842 patients post-myocardial infarction (PMI) were taken 24-96 hours after hospitalization. DNA samples were genotyped for rs6922269, using a TaqMan assay. Homocysteine and active vitamin B12 were measured by immunoassay in baseline CDCS plasma samples, but not PMI plasma. All cause mortality was documented over follow-up of 4.1 (CDCS) and 8.8 (PMI) years, respectively. rs6922269 genotype frequencies were AA n = 135, 7.0%; GA n = 785, 40.5% and GG n = 1020, 52.5% in the CDCS and similar in the PMI cohort. CDCS patients with AA genotype for rs6922269 had lower levels of co-variate adjusted baseline plasma active vitamin B12 (p = 0.017) and poorer survival than patients with GG or GA genotype (mortality: AA 19.6%, GA 12.0%, GG 11.6%; p = 0.007). In multivariate analysis, rs6922269 genotype predicted survival, independent of established covariate predictors (p = 0.03). However the association between genotype and survival was not validated in the PMI cohort. CONCLUSION: MTHFD1L rs6922269 genotype is associated with active vitamin B12 levels at baseline and may be a marker of prognostic risk in patients with established coronary heart disease.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000332842400004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN e89029
dc.identifier.citationPLOS ONE, 2014, 9 (3)
dc.identifier.doi10.1371/journal.pone.0089029
dc.identifier.elements-id201288
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10179/6509
dc.relation.isPartOfPLOS ONE
dc.titleGenetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/School of Health Science
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients..pdf
Size:
671.71 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles