The Global Virome in One Network (VIRION): an Atlas of Vertebrate-Virus Associations

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dc.citation.issue2
dc.citation.volume13
dc.contributor.authorCarlson CJ
dc.contributor.authorGibb RJ
dc.contributor.authorAlbery GF
dc.contributor.authorBrierley L
dc.contributor.authorConnor RP
dc.contributor.authorDallas TA
dc.contributor.authorEskew EA
dc.contributor.authorFagre AC
dc.contributor.authorFarrell MJ
dc.contributor.authorFrank HK
dc.contributor.authorMuylaert RL
dc.contributor.authorPoisot T
dc.contributor.authorRasmussen AL
dc.contributor.authorRyan SJ
dc.contributor.authorSeifert SN
dc.contributor.editorPickett BE
dc.contributor.editorJurado K
dc.coverage.spatialUnited States
dc.date.accessioned2024-01-18T22:51:45Z
dc.date.accessioned2024-07-25T06:43:55Z
dc.date.available2022-03
dc.date.available2024-01-18T22:51:45Z
dc.date.available2024-07-25T06:43:55Z
dc.date.issued2022-04-26
dc.description.abstractData that catalogue viral diversity on Earth have been fragmented across sources, disciplines, formats, and various degrees of open sharing, posing challenges for research on macroecology, evolution, and public health. Here, we solve this problem by establishing a dynamically maintained database of vertebrate-virus associations, called The Global Virome in One Network (VIRION). The VIRION database has been assembled through both reconciliation of static data sets and integration of dynamically updated databases. These data sources are all harmonized against one taxonomic backbone, including metadata on host and virus taxonomic validity and higher classification; additional metadata on sampling methodology and evidence strength are also available in a harmonized format. In total, the VIRION database is the largest open-source, open-access database of its kind, with roughly half a million unique records that include 9,521 resolved virus "species" (of which 1,661 are ICTV ratified), 3,692 resolved vertebrate host species, and 23,147 unique interactions between taxonomically valid organisms. Together, these data cover roughly a quarter of mammal diversity, a 10th of bird diversity, and ∼6% of the estimated total diversity of vertebrates, and a much larger proportion of their virome than any previous database. We show how these data can be used to test hypotheses about microbiology, ecology, and evolution and make suggestions for best practices that address the unique mix of evidence that coexists in these data. IMPORTANCE Animals and their viruses are connected by a sprawling, tangled network of species interactions. Data on the host-virus network are available from several sources, which use different naming conventions and often report metadata in different levels of detail. VIRION is a new database that combines several of these existing data sources, reconciles taxonomy to a single consistent backbone, and reports metadata in a format designed by and for virologists. Researchers can use VIRION to easily answer questions like "Can any fish viruses infect humans?" or "Which bats host coronaviruses?" or to build more advanced predictive models, making it an unprecedented step toward a full inventory of the global virome.
dc.description.confidentialfalse
dc.format.paginatione0298521-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35229639
dc.identifier.citationCarlson CJ, Gibb RJ, Albery GF, Brierley L, Connor RP, Dallas TA, Eskew EA, Fagre AC, Farrell MJ, Frank HK, Muylaert RL, Poisot T, Rasmussen AL, Ryan SJ, Seifert SN. (2022). The Global Virome in One Network (VIRION): an Atlas of Vertebrate-Virus Associations.. mBio. 13. 2. (pp. e0298521-).
dc.identifier.doi10.1128/mbio.02985-21
dc.identifier.eissn2150-7511
dc.identifier.elements-typejournal-article
dc.identifier.issn2161-2129
dc.identifier.numbere02985-21
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70763
dc.languageeng
dc.publisherAmerican Society for Microbiology
dc.publisher.urihttps://journals.asm.org/doi/10.1128/mbio.02985-21
dc.relation.isPartOfmBio
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdata synthesis
dc.subjectecological networks
dc.subjectglobal virome
dc.subjecthost-virus interactions
dc.subjectAnimals
dc.subjectChiroptera
dc.subjectDNA Viruses
dc.subjectVirion
dc.subjectVirome
dc.subjectViruses
dc.titleThe Global Virome in One Network (VIRION): an Atlas of Vertebrate-Virus Associations
dc.typeJournal article
pubs.elements-id453271
pubs.organisational-groupOther
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