Evaluation of a Probability-Based Predictive Tool on Pathologist Agreement Using Urinary Bladder as a Pilot Tissue

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dc.citation.issue7
dc.citation.volume9
dc.contributor.authorJones E
dc.contributor.authorWoldeyohannes S
dc.contributor.authorCastillo-Alcala F
dc.contributor.authorLillie BN
dc.contributor.authorSula M-JM
dc.contributor.authorOwen H
dc.contributor.authorAlawneh J
dc.contributor.authorAllavena R
dc.contributor.editorKim J-H
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-01-17T21:34:02Z
dc.date.accessioned2024-07-25T06:32:27Z
dc.date.available2022-07-18
dc.date.available2024-01-17T21:34:02Z
dc.date.available2024-07-25T06:32:27Z
dc.date.issued2022-07-18
dc.description.abstractInter-pathologist variation is widely recognized across human and veterinary pathology and is often compounded by missing animal or clinical information on pathology submission forms. Variation in pathologist threshold levels of resident inflammatory cells in the tissue of interest can further decrease inter-pathologist agreement. This study applied a predictive modeling tool to bladder histology slides that were assessed by four pathologists: first without animal and clinical information, then with this information, and finally using the predictive tool. All three assessments were performed twice, using digital whole-slide images (WSI) and then glass slides. Results showed marked variation in pathologists' interpretation of bladder slides, with kappa agreement values of 7-37% without any animal or clinical information, 23-37% with animal signalment and history, and 31-42% when our predictive tool was applied, for digital WSI and glass slides. The concurrence of test pathologists to the reference diagnosis was 60% overall. This study provides a starting point for the use of predictive modeling in standardizing pathologist agreement in veterinary pathology. It also highlights the importance of high-quality whole-slide imaging to limit the effect of digitization on inter-pathologist agreement and the benefit of continued standardization of tissue assessment in veterinary pathology.
dc.description.confidentialfalse
dc.edition.editionJuly 2022
dc.format.pagination367-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35878384
dc.identifier.citationJones E, Woldeyohannes S, Castillo-Alcala F, Lillie BN, Sula M-JM, Owen H, Alawneh J, Allavena R. (2022). Evaluation of a Probability-Based Predictive Tool on Pathologist Agreement Using Urinary Bladder as a Pilot Tissue.. Vet Sci. 9. 7. (pp. 367-).
dc.identifier.doi10.3390/vetsci9070367
dc.identifier.eissn2306-7381
dc.identifier.elements-typejournal-article
dc.identifier.issn2306-7381
dc.identifier.number367
dc.identifier.piivetsci9070367
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70381
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2306-7381/9/7/367
dc.relation.isPartOfVet Sci
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbladder disease
dc.subjectcanine
dc.subjectconcurrence
dc.subjectfeline
dc.subjectglass slides
dc.subjectinter-pathologist agreement
dc.subjectpredictive modeling
dc.subjectveterinary pathology
dc.subjectwhole-slide images
dc.titleEvaluation of a Probability-Based Predictive Tool on Pathologist Agreement Using Urinary Bladder as a Pilot Tissue
dc.typeJournal article
pubs.elements-id454935
pubs.organisational-groupOther
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