Canis Familiaris Papillomavirus Type 26: A Novel Papillomavirus of Dogs and the First Canine Papillomavirus within the Omegapapillomavirus Genus.

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dc.citation.issue4
dc.citation.volume16
dc.contributor.authorMunday JS
dc.contributor.authorBond SD
dc.contributor.authorPiripi S
dc.contributor.authorSoulsby SJ
dc.contributor.authorKnox MA
dc.contributor.editorChristensen N
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-09-12T02:53:34Z
dc.date.available2024-09-12T02:53:34Z
dc.date.issued2024-04-12
dc.description.abstractDomestic dogs are currently recognized as being infected by 25 different canine papillomavirus (CPV) types classified into three genera. A short sequence from a novel CPV type was amplified, along with CPV1, from a papilloma (wart) from the mouth of a dog. The entire 7499 bp genome was amplified, and CPV26 contained putative coding regions that were predicted to produce four early proteins and two late ones. The ORF L1 showed less than 62% similarity for all previously sequenced CPV types but over 69% similarity to multiple Omegapapillomavirus types from a variety of Caniform species including the giant panda, Weddel seal, and polar bear. Phylogenetic analysis confirmed CPV26 clusters within the Omegapapillomavirus genus. Specific primers were used to investigate the presence of CPV26 DNA within a series of 37 canine proliferative lesions. CPV26 DNA was amplified from one lesion, a cutaneous papilloma that also contained CPV6. This is the first time a PV type within the Omegapapillomavirus genus has been detected in a non-domestic species and this provides evidence that the omegapapillomaviruses infected a common ancestor of, and then co-evolved with, the Caniform species. Whether CPV26 causes disease is uncertain, but the absence of an E7 protein may suggest low pathogenicity.
dc.description.confidentialfalse
dc.edition.editionApril 2024
dc.format.pagination595-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38675936
dc.identifier.citationMunday JS, Bond SD, Piripi S, Soulsby SJ, Knox MA. (2024). Canis Familiaris Papillomavirus Type 26: A Novel Papillomavirus of Dogs and the First Canine Papillomavirus within the Omegapapillomavirus Genus.. Viruses. 16. 4. (pp. 595-).
dc.identifier.doi10.3390/v16040595
dc.identifier.eissn1999-4915
dc.identifier.elements-typejournal-article
dc.identifier.issn1999-4915
dc.identifier.number595
dc.identifier.piiv16040595
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71447
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/1999-4915/16/4/595
dc.relation.isPartOfViruses
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCPV
dc.subjectCPV26
dc.subjectCaniform
dc.subjectcanine papillomavirus
dc.subjectdog
dc.subjectevolution
dc.subjectomegapapillomavirus
dc.subjectoral papilloma
dc.subjectpapillomavirus
dc.subjectAnimals
dc.subjectDogs
dc.subjectPhylogeny
dc.subjectPapillomavirus Infections
dc.subjectPapillomaviridae
dc.subjectDog Diseases
dc.subjectGenome, Viral
dc.subjectDNA, Viral
dc.subjectOpen Reading Frames
dc.subjectSequence Analysis, DNA
dc.titleCanis Familiaris Papillomavirus Type 26: A Novel Papillomavirus of Dogs and the First Canine Papillomavirus within the Omegapapillomavirus Genus.
dc.typeJournal article
pubs.elements-id488448
pubs.organisational-groupOther
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