A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk.

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dc.citation.issue15
dc.citation.volume83
dc.contributor.authorAglago EK
dc.contributor.authorKim A
dc.contributor.authorLin Y
dc.contributor.authorQu C
dc.contributor.authorEvangelou M
dc.contributor.authorRen Y
dc.contributor.authorMorrison J
dc.contributor.authorAlbanes D
dc.contributor.authorArndt V
dc.contributor.authorBarry EL
dc.contributor.authorBaurley JW
dc.contributor.authorBerndt SI
dc.contributor.authorBien SA
dc.contributor.authorBishop DT
dc.contributor.authorBouras E
dc.contributor.authorBrenner H
dc.contributor.authorBuchanan DD
dc.contributor.authorBudiarto A
dc.contributor.authorCarreras-Torres R
dc.contributor.authorCasey G
dc.contributor.authorCenggoro TW
dc.contributor.authorChan AT
dc.contributor.authorChang-Claude J
dc.contributor.authorChen X
dc.contributor.authorConti DV
dc.contributor.authorDevall M
dc.contributor.authorDiez-Obrero V
dc.contributor.authorDimou N
dc.contributor.authorDrew D
dc.contributor.authorFigueiredo JC
dc.contributor.authorGallinger S
dc.contributor.authorGiles GG
dc.contributor.authorGruber SB
dc.contributor.authorGsur A
dc.contributor.authorGunter MJ
dc.contributor.authorHampel H
dc.contributor.authorHarlid S
dc.contributor.authorHidaka A
dc.contributor.authorHarrison TA
dc.contributor.authorHoffmeister M
dc.contributor.authorHuyghe JR
dc.contributor.authorJenkins MA
dc.contributor.authorJordahl K
dc.contributor.authorJoshi AD
dc.contributor.authorKawaguchi ES
dc.contributor.authorKeku TO
dc.contributor.authorKundaje A
dc.contributor.authorLarsson SC
dc.contributor.authorMarchand LL
dc.contributor.authorLewinger JP
dc.contributor.authorLi L
dc.contributor.authorLynch BM
dc.contributor.authorMahesworo B
dc.contributor.authorMandic M
dc.contributor.authorObón-Santacana M
dc.contributor.authorMoreno V
dc.contributor.authorMurphy N
dc.contributor.authorNan H
dc.contributor.authorNassir R
dc.contributor.authorNewcomb PA
dc.contributor.authorOgino S
dc.contributor.authorOse J
dc.contributor.authorPai RK
dc.contributor.authorPalmer JR
dc.contributor.authorPapadimitriou N
dc.contributor.authorPardamean B
dc.contributor.authorPeoples AR
dc.contributor.authorPlatz EA
dc.contributor.authorPotter JD
dc.contributor.authorPrentice RL
dc.contributor.authorRennert G
dc.contributor.authorRuiz-Narvaez E
dc.contributor.authorSakoda LC
dc.contributor.authorScacheri PC
dc.contributor.authorSchmit SL
dc.contributor.authorSchoen RE
dc.contributor.authorShcherbina A
dc.contributor.authorSlattery ML
dc.contributor.authorStern MC
dc.contributor.authorSu Y-R
dc.contributor.authorTangen CM
dc.contributor.authorThibodeau SN
dc.contributor.authorThomas DC
dc.contributor.authorTian Y
dc.contributor.authorUlrich CM
dc.contributor.authorvan Duijnhoven FJ
dc.contributor.authorVan Guelpen B
dc.contributor.authorVisvanathan K
dc.contributor.authorVodicka P
dc.contributor.authorWang J
dc.contributor.authorWhite E
dc.contributor.authorWolk A
dc.contributor.authorWoods MO
dc.contributor.authorWu AH
dc.contributor.authorZemlianskaia N
dc.contributor.authorHsu L
dc.contributor.authorGauderman WJ
dc.contributor.authorPeters U
dc.contributor.authorTsilidis KK
dc.contributor.authorCampbell PT
dc.coverage.spatialUnited States
dc.date.accessioned2024-07-04T21:38:37Z
dc.date.available2024-07-04T21:38:37Z
dc.date.issued2023-08-01
dc.description.abstractColorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment interactions (G × E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G × E interactions between body mass index (BMI) and common SNPs for colorectal cancer risk using data from 36,415 colorectal cancer cases and 48,451 controls from three international colorectal cancer consortia (CCFR, CORECT, and GECCO). The G × E tests included the conventional logistic regression using multiplicative terms (one degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G × E interactions under specific conditions. BMI was associated with higher colorectal cancer risk. The two-step approach revealed a statistically significant G×BMI interaction located within the Formin 1/Gremlin 1 (FMN1/GREM1) gene region (rs58349661). This SNP was also identified by the 3DF test, with a suggestive statistical significance in the 1DF test. Among participants with the CC genotype of rs58349661, overweight and obesity categories were associated with higher colorectal cancer risk, whereas null associations were observed across BMI categories in those with the TT genotype. Using data from three large international consortia, this study discovered a locus in the FMN1/GREM1 gene region that interacts with BMI on the association with colorectal cancer risk. Further studies should examine the potential mechanisms through which this locus modifies the etiologic link between obesity and colorectal cancer. Significance: This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies.
dc.description.confidentialfalse
dc.format.pagination2572-2583
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37249599
dc.identifier.citationAglago EK, Kim A, Lin Y, Qu C, Evangelou M, Ren Y, Morrison J, Albanes D, Arndt V, Barry EL, Baurley JW, Berndt SI, Bien SA, Bishop DT, Bouras E, Brenner H, Buchanan DD, Budiarto A, Carreras-Torres R, Casey G, Cenggoro TW, Chan AT, Chang-Claude J, Chen X, Conti DV, Devall M, Diez-Obrero V, Dimou N, Drew D, Figueiredo JC, Gallinger S, Giles GG, Gruber SB, Gsur A, Gunter MJ, Hampel H, Harlid S, Hidaka A, Harrison TA, Hoffmeister M, Huyghe JR, Jenkins MA, Jordahl K, Joshi AD, Kawaguchi ES, Keku TO, Kundaje A, Larsson SC, Marchand LL, Lewinger JP, Li L, Lynch BM, Mahesworo B, Mandic M, Obón-Santacana M, Moreno V, Murphy N, Nan H, Nassir R, Newcomb PA, Ogino S, Ose J, Pai RK, Palmer JR, Papadimitriou N, Pardamean B, Peoples AR, Platz EA, Potter JD, Prentice RL, Rennert G, Ruiz-Narvaez E, Sakoda LC, Scacheri PC, Schmit SL, Schoen RE, Shcherbina A, Slattery ML, Stern MC, Su Y-R, Tangen CM, Thibodeau SN, Thomas DC, Tian Y, Ulrich CM, van Duijnhoven FJ, Van Guelpen B, Visvanathan K, Vodicka P, Wang J, White E, Wolk A, Woods MO, Wu AH, Zemlianskaia N, Hsu L, Gauderman WJ, Peters U, Tsilidis KK, Campbell PT. (2023). A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk.. Cancer Res. 83. 15. (pp. 2572-2583).
dc.identifier.doi10.1158/0008-5472.CAN-22-3713
dc.identifier.eissn1538-7445
dc.identifier.elements-typejournal-article
dc.identifier.issn0008-5472
dc.identifier.pii727007
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70092
dc.languageeng
dc.publisherAmerican Association for Cancer Research
dc.publisher.urihttps://aacrjournals.org/cancerres/article/83/15/2572/728086/A-Genetic-Locus-within-the-FMN1-GREM1-Gene-Region
dc.relation.isPartOfCancer Res
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectBody Mass Index
dc.subjectRisk Factors
dc.subjectObesity
dc.subjectGenetic Loci
dc.subjectColorectal Neoplasms
dc.subjectPolymorphism, Single Nucleotide
dc.subjectGenetic Predisposition to Disease
dc.subjectGenome-Wide Association Study
dc.subjectIntercellular Signaling Peptides and Proteins
dc.titleA Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk.
dc.typeJournal article
pubs.elements-id461895
pubs.organisational-groupCollege of Health
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