Cerebrovascular and cardiovascular responses to the Valsalva manoeuvre during hyperthermia.
dc.citation.issue | 6 | |
dc.citation.volume | 43 | |
dc.contributor.author | Perry BG | |
dc.contributor.author | Korad S | |
dc.contributor.author | Mündel T | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2024-06-17T01:49:41Z | |
dc.date.available | 2024-06-17T01:49:41Z | |
dc.date.issued | 2023-06-18 | |
dc.description.abstract | BACKGROUND: During hyperthermia, the perturbations in mean arterial blood pressure (MAP) produced by the Valsalva manoeuvre (VM) are more severe. However, whether these more severe VM-induced changes in MAP are translated to the cerebral circulation during hyperthermia is unclear. METHODS: Healthy participants (n = 12, 1 female, mean ± SD: age 24 ± 3 years) completed a 30 mmHg (mouth pressure) VM for 15 s whilst supine during normothermia and mild hyperthermia. Hyperthermia was induced passively using a liquid conditioning garment with core temperature measured via ingested temperature sensor. Middle cerebral artery blood velocity (MCAv) and MAP were recorded continuously during and post-VM. Tieck's autoregulatory index was calculated from the VM responses, with pulsatility index, an index of pulse velocity (pulse time) and mean MCAv (MCAvmean ) also calculated. RESULTS: Passive heating significantly raised core temperature from baseline (37.9 ± 0.2 vs. 37.1 ± 0.1°C at rest, p < 0.01). MAP during phases I through III of the VM was lower during hyperthermia (interaction effect p < 0.01). Although an interaction effect was observed for MCAvmean (p = 0.02), post-hoc differences indicated only phase IIa was lower during hyperthermia (55 ± 12 vs. 49.3 ± 8 cm s- 1 for normothermia and hyperthermia, respectively, p = 0.03). Pulsatility index was increased 1-min post-VM in both conditions (0.71 ± 0.11 vs. 0.76 ± 0.11 for pre- and post-VM during normothermia, respectively, p = 0.02, and 0.86 ± 0.11 vs. 0.99 ± 0.09 for hyperthermia p < 0.01), although for pulse time only main effects of time (p < 0.01), and condition (p < 0.01) were apparent. CONCLUSION: These data indicate that the cerebrovascular response to the VM is largely unchanged by mild hyperthermia. | |
dc.description.confidential | false | |
dc.edition.edition | Nov 2023 | |
dc.format.pagination | 463-471 | |
dc.identifier.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37332243 | |
dc.identifier.citation | Perry BG, Korad S, Mündel T. (2023). Cerebrovascular and cardiovascular responses to the Valsalva manoeuvre during hyperthermia.. Clin Physiol Funct Imaging. 43. 6. (pp. 463-471). | |
dc.identifier.doi | 10.1111/cpf.12843 | |
dc.identifier.eissn | 1475-097X | |
dc.identifier.elements-type | journal-article | |
dc.identifier.issn | 1475-0961 | |
dc.identifier.uri | https://mro.massey.ac.nz/handle/10179/69861 | |
dc.language | eng | |
dc.publisher | John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine | |
dc.publisher.uri | https://onlinelibrary.wiley.com/doi/10.1111/cpf.12843 | |
dc.relation.isPartOf | Clin Physiol Funct Imaging | |
dc.rights | (c) 2023 The Author/s | |
dc.rights | CC BY 4.0 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | blood pressure | |
dc.subject | cerebral autoregulation | |
dc.subject | cerebral blood flow | |
dc.subject | heat stress | |
dc.subject | middle cerebral artery blood velocity | |
dc.subject | Humans | |
dc.subject | Female | |
dc.subject | Young Adult | |
dc.subject | Adult | |
dc.subject | Valsalva Maneuver | |
dc.subject | Middle Cerebral Artery | |
dc.subject | Homeostasis | |
dc.subject | Cerebrovascular Circulation | |
dc.subject | Hyperthermia, Induced | |
dc.subject | Blood Flow Velocity | |
dc.subject | Blood Pressure | |
dc.title | Cerebrovascular and cardiovascular responses to the Valsalva manoeuvre during hyperthermia. | |
dc.type | Journal article | |
pubs.elements-id | 462215 | |
pubs.organisational-group | College of Health |