Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction

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dc.citation.issue1
dc.citation.volume9
dc.contributor.authorBassett SA
dc.contributor.authorYoung W
dc.contributor.authorFraser K
dc.contributor.authorDalziel JE
dc.contributor.authorWebster J
dc.contributor.authorRyan L
dc.contributor.authorFitzgerald P
dc.contributor.authorStanton C
dc.contributor.authorDinan TG
dc.contributor.authorCryan JF
dc.contributor.authorClarke G
dc.contributor.authorHyland N
dc.contributor.authorRoy NC
dc.coverage.spatialEngland
dc.date.accessioned2024-10-18T01:25:13Z
dc.date.available2024-10-18T01:25:13Z
dc.date.issued2019-10-01
dc.description.abstractStress negatively impacts gut and brain health. Individual differences in response to stress have been linked to genetic and environmental factors and more recently, a role for the gut microbiota in the regulation of stress-related changes has been demonstrated. However, the mechanisms by which these factors influence each other are poorly understood, and there are currently no established robust biomarkers of stress susceptibility. To determine the metabolic and microbial signatures underpinning physiological stress responses, we compared stress-sensitive Wistar Kyoto (WKY) rats to the normo-anxious Sprague Dawley (SD) strain. Here we report that acute stress-induced strain-specific changes in brain lipid metabolites were a prominent feature in WKY rats. The relative abundance of Lactococcus correlated with the relative proportions of many brain lipids. In contrast, plasma lipids were significantly elevated in response to stress in SD rats, but not in WKY rats. Supporting these findings, we found that the greatest difference between the SD and WKY microbiomes were the predicted relative abundance of microbial genes involved in lipid and energy metabolism. Our results provide potential insights for developing novel biomarkers of stress vulnerability, some of which appear genotype specific.
dc.description.confidentialfalse
dc.format.pagination14026-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31575902
dc.identifier.citationBassett SA, Young W, Fraser K, Dalziel JE, Webster J, Ryan L, Fitzgerald P, Stanton C, Dinan TG, Cryan JF, Clarke G, Hyland N, Roy NC. (2019). Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction.. Sci Rep. 9. 1. (pp. 14026-).
dc.identifier.doi10.1038/s41598-019-50593-3
dc.identifier.eissn2045-2322
dc.identifier.elements-typejournal-article
dc.identifier.issn2045-2322
dc.identifier.numberARTN 14026
dc.identifier.pii10.1038/s41598-019-50593-3
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71758
dc.languageeng
dc.publisherSpringer Nature Limited
dc.publisher.urihttps://www.nature.com/articles/s41598-019-50593-3
dc.relation.isPartOfSci Rep
dc.rights(c) 2019 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectBrain
dc.subjectDisease Models, Animal
dc.subjectGastrointestinal Microbiome
dc.subjectLactococcus
dc.subjectLipid Metabolism
dc.subjectLipids
dc.subjectMale
dc.subjectMetabolome
dc.subjectRats
dc.subjectRats, Inbred WKY
dc.subjectRats, Sprague-Dawley
dc.subjectStress, Physiological
dc.titleMetabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction
dc.typeJournal article
pubs.elements-id434467
pubs.organisational-groupOther
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