Toxicological Assessment of Pure Lolitrem B and Ryegrass Seed Infected with the AR37 Endophyte Using Mice

Simple item page
dc.citation.issue11
dc.citation.volume8
dc.contributor.authorFinch SC
dc.contributor.authorHawkes AD
dc.contributor.authorFitzgerald JM
dc.contributor.authorBroadhurst RB
dc.contributor.authorStaincliffe MR
dc.contributor.authorMunday JS
dc.contributor.editorNewman J
dc.contributor.editorJohnson L
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-02-05T01:55:29Z
dc.date.accessioned2024-07-25T06:47:43Z
dc.date.available2022-10-28
dc.date.available2024-02-05T01:55:29Z
dc.date.available2024-07-25T06:47:43Z
dc.date.issued2022-10-28
dc.description.abstractFungal endophytes in perennial ryegrass are essential to New Zealand's pastoral system due to anti-insect effects. However, endophytes also produce compounds which can be detrimental to animals. Furthermore, as these toxins have been detected in the milk and fat of animals grazing common-toxic (containing lolitrem B) or AR37 endophyte-infected herbage they could enter the human food chain. To assess the risk to human health mice were fed for 90 days with three dose rates of lolitrem B and of AR37. Parameters indicative of animal health were measured as well as chemical, hematological and histological analysis of samples collected on day 90. Since endophyte toxin residues have been detected in milk, they could be transferred from mother to offspring via breast milk. To evaluate possible effects on reproduction two complete generations of mice were fed lolitrem B or AR37. At the dose rates given no adverse effects were observed in either study. The 100-fold safety factor to allow the use of animal data in human health assessments was applied and by considering the concentrations of lolitrem B or AR37 metabolites which could be ingested by a consumer it is highly unlikely that they pose any risk to human health.
dc.description.confidentialfalse
dc.edition.editionNovember 2022
dc.format.pagination1139-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36354906
dc.identifier.citationFinch SC, Hawkes AD, Fitzgerald JM, Broadhurst RB, Staincliffe MR, Munday JS. (2022). Toxicological Assessment of Pure Lolitrem B and Ryegrass Seed Infected with the AR37 Endophyte Using Mice.. J Fungi (Basel). 8. 11. (pp. 1139-).
dc.identifier.doi10.3390/jof8111139
dc.identifier.eissn2309-608X
dc.identifier.elements-typejournal-article
dc.identifier.issn2309-608X
dc.identifier.number1139
dc.identifier.piijof8111139
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70890
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2309-608X/8/11/1139
dc.relation.isPartOfJ Fungi (Basel)
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectepoxyjanthitrems
dc.subjectfeeding study
dc.subjectlolitrem B
dc.subjectreproduction study
dc.subjecttoxicology
dc.titleToxicological Assessment of Pure Lolitrem B and Ryegrass Seed Infected with the AR37 Endophyte Using Mice
dc.typeJournal article
pubs.elements-id457878
pubs.organisational-groupOther
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