Differential Gene Expression Associated with Soybean Oil Level in the Diet of Pigs

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dc.citation.issue13
dc.citation.volume12
dc.contributor.authorFanalli SL
dc.contributor.authorda Silva BPM
dc.contributor.authorGomes JD
dc.contributor.authorde Almeida VV
dc.contributor.authorFreitas FAO
dc.contributor.authorMoreira GCM
dc.contributor.authorSilva-Vignato B
dc.contributor.authorAfonso J
dc.contributor.authorReecy J
dc.contributor.authorKoltes J
dc.contributor.authorKoltes D
dc.contributor.authorde Almeida Regitano LC
dc.contributor.authorGarrick DJ
dc.contributor.authorde Carvalho Balieiro JC
dc.contributor.authorMeira AN
dc.contributor.authorFreitas L
dc.contributor.authorCoutinho LL
dc.contributor.authorFukumasu H
dc.contributor.authorMourão GB
dc.contributor.authorde Alencar SM
dc.contributor.authorLuchiari Filho A
dc.contributor.authorCesar ASM
dc.contributor.editorHernandez P
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-05-15T22:56:21Z
dc.date.available2024-05-15T22:56:21Z
dc.date.issued2022-06-25
dc.description.abstractThe aim of this study was to identify the differentially expressed genes (DEG) from the skeletal muscle and liver samples of animal models for metabolic diseases in humans. To perform the study, the fatty acid (FA) profile and RNA sequencing (RNA-Seq) data of 35 samples of liver tissue (SOY1.5, n = 17 and SOY3.0, n = 18) and 36 samples of skeletal muscle (SOY1.5, n = 18 and SOY3.0, n = 18) of Large White pigs were analyzed. The FA profile of the tissues was modified by the diet, mainly those related to monounsaturated (MUFA) and polyunsaturated (PUFA) FA. The skeletal muscle transcriptome analysis revealed 45 DEG (FDR 10%), and the functional enrichment analysis identified network maps related to inflammation, immune processes, and pathways associated with oxidative stress, type 2 diabetes, and metabolic dysfunction. For the liver tissue, the transcriptome profile analysis revealed 281 DEG, which participate in network maps related to neurodegenerative diseases. With this nutrigenomics study, we verified that different levels of soybean oil in the pig diet, an animal model for metabolic diseases in humans, affected the transcriptome profile of skeletal muscle and liver tissue. These findings may help to better understand the biological mechanisms that can be modulated by the diet.
dc.description.confidentialfalse
dc.edition.editionJuly-1 2023
dc.format.pagination1632-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35804531
dc.identifier.citationFanalli SL, da Silva BPM, Gomes JD, de Almeida VV, Freitas FAO, Moreira GCM, Silva-Vignato B, Afonso J, Reecy J, Koltes J, Koltes D, de Almeida Regitano LC, Garrick DJ, de Carvalho Balieiro JC, Meira AN, Freitas L, Coutinho LL, Fukumasu H, Mourão GB, de Alencar SM, Luchiari Filho A, Cesar ASM. (2022). Differential Gene Expression Associated with Soybean Oil Level in the Diet of Pigs.. Animals (Basel). 12. 13. (pp. 1632-).
dc.identifier.doi10.3390/ani12131632
dc.identifier.eissn2076-2615
dc.identifier.elements-typejournal-article
dc.identifier.issn2076-2615
dc.identifier.number1632
dc.identifier.piiani12131632
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69575
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2076-2615/12/13/1632
dc.relation.isPartOfAnimals (Basel)
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectLongissimus lomborum
dc.subjectRNAseq
dc.subjectanimal model
dc.subjectfatty acid
dc.subjecthepatic tissue
dc.subjectimmune response
dc.subjectmetabolism
dc.subjecttranscriptome
dc.titleDifferential Gene Expression Associated with Soybean Oil Level in the Diet of Pigs
dc.typeJournal article
pubs.elements-id454749
pubs.organisational-groupOther
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