Endocrine fibroblast growth factors in domestic animals.

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dc.citation.volume89
dc.contributor.authorBrinker EJ
dc.contributor.authorHardcastle MR
dc.contributor.authorDittmer KE
dc.contributor.authorGraff EC
dc.coverage.spatialUnited States
dc.date.accessioned2024-08-06T02:35:29Z
dc.date.available2024-08-06T02:35:29Z
dc.date.issued2024-07-09
dc.description.abstractFibroblast growth factors (FGFs) are a group of structurally homologous yet functionally pleiotropic proteins. Canonical and intracellular FGFs have primarily autocrine or paracrine effects. However, the FGF19 subfamily, composed of FGF15/19, FGF21, and FGF23, act as endocrine hormones that regulate bile acid, metabolic, and phosphorus homeostasis, respectively. Current research in human and rodent models demonstrates the potential of these endocrine FGFs to target various diseases, including disorders of inherited hypophosphatemia, chronic liver disease, obesity, and insulin resistance. Many diseases targeted for therapeutic use in humans have pathophysiological overlaps in domestic animals. Despite the potential clinical and economic impact, little is known about endocrine FGFs and their signaling pathways in major domestic animal species compared with humans and laboratory animals. This review aims to describe the physiology of these endocrine FGFs, discuss their current therapeutic use, and summarize the contemporary literature regarding endocrine FGFs in domestic animals, focusing on potential future directions.
dc.description.confidentialfalse
dc.edition.editionOctober 2024
dc.format.pagination106872-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/39059301
dc.identifier.citationBrinker EJ, Hardcastle MR, Dittmer KE, Graff EC. (2024). Endocrine fibroblast growth factors in domestic animals.. Domest Anim Endocrinol. 89. (pp. 106872-).
dc.identifier.doi10.1016/j.domaniend.2024.106872
dc.identifier.eissn1879-0054
dc.identifier.elements-typejournal-article
dc.identifier.issn0739-7240
dc.identifier.number106872
dc.identifier.piiS0739-7240(24)00035-3
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71210
dc.languageeng
dc.publisherElsevier B.V.
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0739724024000353?
dc.relation.isPartOfDomest Anim Endocrinol
dc.rights(c) 2024 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectDomestic animals
dc.subjectEndocrine FGFs
dc.subjectFGF19
dc.subjectFGF21
dc.subjectFGF23
dc.subjectFibroblast growth factors
dc.titleEndocrine fibroblast growth factors in domestic animals.
dc.typeJournal article
pubs.elements-id490952
pubs.organisational-groupOther
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