Campylobacter colonization and undernutrition in infants in rural eastern Ethiopia - a longitudinal community-based birth cohort study.

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dc.citation.volume12
dc.contributor.authorChen D
dc.contributor.authorMcKune SL
dc.contributor.authorYang Y
dc.contributor.authorUsmane IA
dc.contributor.authorAhmed IA
dc.contributor.authorAmin JK
dc.contributor.authorIbrahim AM
dc.contributor.authorSeran AJ
dc.contributor.authorShaik N
dc.contributor.authorOjeda A
dc.contributor.authorHassen BM
dc.contributor.authorDeblais L
dc.contributor.authorAhmedo BU
dc.contributor.authorHassen KA
dc.contributor.authorBhrane M
dc.contributor.authorLi X
dc.contributor.authorSingh N
dc.contributor.authorRoba KT
dc.contributor.authorFrench NP
dc.contributor.authorRajashekara G
dc.contributor.authorManary MJ
dc.contributor.authorHassen JY
dc.contributor.authorHavelaar AH
dc.contributor.authorCAGED Research Team
dc.coverage.spatialSwitzerland
dc.date.accessioned2025-02-19T23:49:47Z
dc.date.available2025-02-19T23:49:47Z
dc.date.issued2025-01-07
dc.description.abstractBackground: Campylobacter is associated with environmental enteric dysfunction (EED) and malnutrition in children. Campylobacter infection could be a linchpin between livestock fecal exposure and health outcomes in low-resource smallholder settings. Methods: We followed a birth cohort of 106 infants in rural smallholder households in eastern Ethiopia up to 13 months of age. We measured anthropometry, surveyed sociodemographic determinants, and collected stool and urine samples. A short survey was conducted during monthly visits, infant stool samples were collected, and Campylobacter spp. was quantified using genus-specific qPCR. In month 13, we collected stool and urine samples to assay for EED biomarkers. We employed regression analyses to assess the associations of household determinants with Campylobacter colonization, EED, and growth faltering. Results: The Campylobacter load in infant stools increased with age. The mean length-for-age Z-score (LAZ) decreased from −0.45 at 3–4 months of age to −2.06 at 13 months, while the prevalence of stunting increased from 3 to 51%. The prevalence of EED at 13 months of age was 56%. A higher Campylobacter load was associated with more frequent diarrhea. Prelacteal feeding significantly increased Campylobacter load in the first month of life. Over the whole follow-up period, Campylobacter load was increased by keeping chickens unconfined at home and unsanitary disposal of infant stools while decreased by mothers’ handwashing with soap. Longitudinally, Campylobacter load was positively associated with food insecurity, introduction of complementary foods, and raw milk consumption. There were no significant associations between Campylobacter load, EED, and LAZ. Conclusion: This study found that most determinants associated with increased Campylobacter infection were related to suboptimal feeding practices and hygiene. The findings related to livestock-associated risks were inconclusive. Although stunting, EED, and Campylobacter prevalence rates all increased to high levels by the end of the first year of life, no significant association between them was identified. While additional research is needed to investigate whether findings from this study are replicable in other populations, community efforts to improve infant and young child feeding practices and food hygiene, and water, sanitation, and hygiene (WaSH) at the household level, could reduce (cross-)contamination at the point of exposure.
dc.description.confidentialfalse
dc.format.pagination1467462-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/39839388
dc.identifier.citationChen D, McKune SL, Yang Y, Usmane IA, Ahmed IA, Amin JK, Ibrahim AM, Seran AJ, Shaik N, Ojeda A, Hassen BM, Deblais L, Ahmedo BU, Hassen KA, Bhrane M, Li X, Singh N, Roba KT, French NP, Rajashekara G, Manary MJ, Hassen JY, Havelaar AH, CAGED Research Team . (2024). Campylobacter colonization and undernutrition in infants in rural eastern Ethiopia - a longitudinal community-based birth cohort study.. Front Public Health. 12. (pp. 1467462-).
dc.identifier.doi10.3389/fpubh.2024.1467462
dc.identifier.eissn2296-2565
dc.identifier.elements-typejournal-article
dc.identifier.issn2296-2565
dc.identifier.number1467462
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72516
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttp://frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1467462/full
dc.relation.isPartOfFront Public Health
dc.rights(c) 2025 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCampylobacter
dc.subjectEthiopia
dc.subjectenvironmental enteric dysfunction
dc.subjectlongitudinal study
dc.subjectprospective birth cohort
dc.subjectsmallholder livestock farming
dc.subjectundernutrition
dc.subjectHumans
dc.subjectInfant
dc.subjectEthiopia
dc.subjectFemale
dc.subjectRural Population
dc.subjectMale
dc.subjectCampylobacter Infections
dc.subjectCampylobacter
dc.subjectLongitudinal Studies
dc.subjectFeces
dc.subjectMalnutrition
dc.subjectPrevalence
dc.subjectInfant, Newborn
dc.subjectAnimals
dc.subjectCohort Studies
dc.titleCampylobacter colonization and undernutrition in infants in rural eastern Ethiopia - a longitudinal community-based birth cohort study.
dc.typeJournal article
pubs.elements-id499453
pubs.organisational-groupOther
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