Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.

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dc.citation.issue1
dc.citation.volume11
dc.contributor.authorStrakova A
dc.contributor.authorNicholls TJ
dc.contributor.authorBaez-Ortega A
dc.contributor.authorNí Leathlobhair M
dc.contributor.authorSampson AT
dc.contributor.authorHughes K
dc.contributor.authorBolton IAG
dc.contributor.authorGori K
dc.contributor.authorWang J
dc.contributor.authorAirikkala-Otter I
dc.contributor.authorAllen JL
dc.contributor.authorAllum KM
dc.contributor.authorArnold CL
dc.contributor.authorBansse-Issa L
dc.contributor.authorBhutia TN
dc.contributor.authorBisson JL
dc.contributor.authorBlank K
dc.contributor.authorBriceño C
dc.contributor.authorCastillo Domracheva A
dc.contributor.authorCorrigan AM
dc.contributor.authorCran HR
dc.contributor.authorCrawford JT
dc.contributor.authorCutter SM
dc.contributor.authorDavis E
dc.contributor.authorde Castro KF
dc.contributor.authorDe Nardi AB
dc.contributor.authorde Vos AP
dc.contributor.authorDelgadillo Keenan L
dc.contributor.authorDonelan EM
dc.contributor.authorEspinoza Huerta AR
dc.contributor.authorFaramade IA
dc.contributor.authorFazil M
dc.contributor.authorFotopoulou E
dc.contributor.authorFruean SN
dc.contributor.authorGallardo-Arrieta F
dc.contributor.authorGlebova O
dc.contributor.authorGouletsou PG
dc.contributor.authorHäfelin Manrique RF
dc.contributor.authorHenriques JJGP
dc.contributor.authorHorta RS
dc.contributor.authorIgnatenko N
dc.contributor.authorKane Y
dc.contributor.authorKing C
dc.contributor.authorKoenig D
dc.contributor.authorKrupa A
dc.contributor.authorKruzeniski SJ
dc.contributor.authorLanza-Perea M
dc.contributor.authorLazyan M
dc.contributor.authorLopez Quintana AM
dc.contributor.authorLosfelt T
dc.contributor.authorMarino G
dc.contributor.authorMartínez Castañeda S
dc.contributor.authorMartínez-López MF
dc.contributor.authorMasuruli BM
dc.contributor.authorMeyer M
dc.contributor.authorMigneco EJ
dc.contributor.authorNakanwagi B
dc.contributor.authorNeal KB
dc.contributor.authorNeunzig W
dc.contributor.authorNixon SJ
dc.contributor.authorOrtega-Pacheco A
dc.contributor.authorPedraza-Ordoñez F
dc.contributor.authorPeleteiro MC
dc.contributor.authorPolak K
dc.contributor.authorPye RJ
dc.contributor.authorRamirez-Ante JC
dc.contributor.authorReece JF
dc.contributor.authorRojas Gutierrez J
dc.contributor.authorSadia H
dc.contributor.authorSchmeling SK
dc.contributor.authorShamanova O
dc.contributor.authorSherlock AG
dc.contributor.authorSteenland-Smit AE
dc.contributor.authorSvitich A
dc.contributor.authorTapia Martínez LJ
dc.contributor.authorThoya Ngoka I
dc.contributor.authorTorres CG
dc.contributor.authorTudor EM
dc.contributor.authorvan der Wel MG
dc.contributor.authorVițălaru BA
dc.contributor.authorVural SA
dc.contributor.authorWalkinton O
dc.contributor.authorWehrle-Martinez AS
dc.contributor.authorWiddowson SAE
dc.contributor.authorZvarich I
dc.contributor.authorChinnery PF
dc.contributor.authorFalkenberg M
dc.contributor.authorGustafsson CM
dc.contributor.authorMurchison EP
dc.coverage.spatialEngland
dc.date.accessioned2024-07-24T00:00:10Z
dc.date.available2024-07-24T00:00:10Z
dc.date.issued2020-06-16
dc.description.abstractAutonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.
dc.description.confidentialfalse
dc.edition.edition2020
dc.format.pagination3059-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32546718
dc.identifier.citationStrakova A, Nicholls TJ, Baez-Ortega A, Ní Leathlobhair M, Sampson AT, Hughes K, Bolton IAG, Gori K, Wang J, Airikkala-Otter I, Allen JL, Allum KM, Arnold CL, Bansse-Issa L, Bhutia TN, Bisson JL, Blank K, Briceño C, Castillo Domracheva A, Corrigan AM, Cran HR, Crawford JT, Cutter SM, Davis E, de Castro KF, De Nardi AB, de Vos AP, Delgadillo Keenan L, Donelan EM, Espinoza Huerta AR, Faramade IA, Fazil M, Fotopoulou E, Fruean SN, Gallardo-Arrieta F, Glebova O, Gouletsou PG, Häfelin Manrique RF, Henriques JJGP, Horta RS, Ignatenko N, Kane Y, King C, Koenig D, Krupa A, Kruzeniski SJ, Lanza-Perea M, Lazyan M, Lopez Quintana AM, Losfelt T, Marino G, Martínez Castañeda S, Martínez-López MF, Masuruli BM, Meyer M, Migneco EJ, Nakanwagi B, Neal KB, Neunzig W, Nixon SJ, Ortega-Pacheco A, Pedraza-Ordoñez F, Peleteiro MC, Polak K, Pye RJ, Ramirez-Ante JC, Reece JF, Rojas Gutierrez J, Sadia H, Schmeling SK, Shamanova O, Sherlock AG, Steenland-Smit AE, Svitich A, Tapia Martínez LJ, Thoya Ngoka I, Torres CG, Tudor EM, van der Wel MG, Vițălaru BA, Vural SA, Walkinton O, Wehrle-Martinez AS, Widdowson SAE, Zvarich I, Chinnery PF, Falkenberg M, Gustafsson CM, Murchison EP. (2020). Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.. Nat Commun. 11. 1. (pp. 3059-).
dc.identifier.doi10.1038/s41467-020-16765-w
dc.identifier.eissn2041-1723
dc.identifier.elements-typejournal-article
dc.identifier.issn2041-1723
dc.identifier.number3059
dc.identifier.pii10.1038/s41467-020-16765-w
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70298
dc.languageeng
dc.publisherSpringer Nature Limited
dc.publisher.urihttps://www.nature.com/articles/s41467-020-16765-w
dc.relation.isPartOfNat Commun
dc.rights(c) 2020 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectDNA, Mitochondrial
dc.subjectDog Diseases
dc.subjectDogs
dc.subjectGene Transfer, Horizontal
dc.subjectHaplotypes
dc.subjectPhylogeny
dc.subjectPolymorphism, Genetic
dc.subjectRecurrence
dc.subjectSelection, Genetic
dc.subjectVenereal Tumors, Veterinary
dc.titleRecurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.
dc.typeJournal article
pubs.elements-id457304
pubs.organisational-groupOther
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