Prevalence and genetic diversity of Theileria equi from horses in Xinjiang Uygur Autonomous region, China.

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dc.citation.issue4
dc.citation.volume14
dc.contributor.authorZhang Y
dc.contributor.authorShi Q
dc.contributor.authorLaven R
dc.contributor.authorLi C
dc.contributor.authorHe W
dc.contributor.authorZheng H
dc.contributor.authorLiu S
dc.contributor.authorLu M
dc.contributor.authorYang DA
dc.contributor.authorGuo Q
dc.contributor.authorChahan B
dc.coverage.spatialNetherlands
dc.date.accessioned2024-08-21T20:38:49Z
dc.date.available2024-08-21T20:38:49Z
dc.date.issued2023-07-01
dc.description.abstractTheileria equi is a tick-borne intracellular apicomplexan protozoan parasite that causes equine theileriosis (ET). ET is an economically important disease with a worldwide distribution that significantly impacts international horse movement. Horses are an essential part of the economy in Xinjiang which is home to ∼10% of all the horses in China. However, there is very limited information on the prevalence and genetic complexity of T. equi in this region. Blood samples from 302 horses were collected from May to September 2021 in Ili, Xinjiang, and subjected to PCR examination for the presence of T. equi. In addition, a Bayesian latent class model was employed to estimate the true prevalence of T. equi, and a phylogenetic analysis was carried out based on the 18S rRNA gene of T. equi isolates. Seventy-two horses (23.8%) were PCR positive. After accounting for the imperfect PCR test using a Bayesian latent class model, the estimated true prevalence differed considerably between age groups, being 10.8% (95%CrI: 5.8% - 17.9%) in ≤ 3-year-old horses and 35.7% (95%CrI: 28.1% - 44.5%) in horses that were > 3 year-old. All T. equi isolates had their 18S rRNA gene (430bp) sequenced and analyzed in order to identify whether there were multiple genotypes of T. equi in the Xinjiang horse population. All of the 18S rRNA genes clustered into one phylogenetic group, clade E, which is thus probably the dominant genotype of T. equi in Xinjiang, China. To summarize, we monitored the prevalence of T. equi in horses of Xinjiang, China, with a focus on the association between age and the occurrence of T. equi by Bayesian modelling, accompanied by the genotyping of T. equi isolates. Obtaining the information on genotypes and age structure is significant in monitoring the spread of T. equi and studying the factors responsible for the distribution.
dc.description.confidentialfalse
dc.edition.editionJuly 2023
dc.format.pagination102193-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37150103
dc.identifier.citationZhang Y, Shi Q, Laven R, Li C, He W, Zheng H, Liu S, Lu M, Yang DA, Guo Q, Chahan B. (2023). Prevalence and genetic diversity of Theileria equi from horses in Xinjiang Uygur Autonomous region, China.. Ticks Tick Borne Dis. 14. 4. (pp. 102193-).
dc.identifier.doi10.1016/j.ttbdis.2023.102193
dc.identifier.eissn1877-9603
dc.identifier.elements-typejournal-article
dc.identifier.issn1877-959X
dc.identifier.number102193
dc.identifier.piiS1877-959X(23)00074-2
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71355
dc.languageeng
dc.publisherElsevier B.V.
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S1877959X23000742?
dc.relation.isPartOfTicks Tick Borne Dis
dc.rights(c) 2023 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBayesian modelling
dc.subjectEquine, Theileria equi
dc.subjectGenotype
dc.subjectMolecular epidemiology
dc.subjectCattle
dc.subjectHorses
dc.subjectAnimals
dc.subjectTheileria
dc.subjectPrevalence
dc.subjectPhylogeny
dc.subjectBayes Theorem
dc.subjectTheileriasis
dc.subjectGenetic Variation
dc.subjectHorse Diseases
dc.subjectBabesiosis
dc.titlePrevalence and genetic diversity of Theileria equi from horses in Xinjiang Uygur Autonomous region, China.
dc.typeJournal article
pubs.elements-id461660
pubs.organisational-groupOther
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