Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network
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Date
2021-12
Open Access Location
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier B.V
Rights
(c) 2021 The Author/s
CC BY-NC-ND 4.0
CC BY-NC-ND 4.0
Abstract
Understanding the relative contribution of different between-farm transmission pathways is essential in guiding recommendations for mitigating disease spread. This study investigated the association between contact pathways linking poultry farms in New Zealand and the genetic relatedness of antimicrobial resistant Campylobacter jejuni Sequence Type 6964 (ST-6964), with the aim of identifying the most likely contact pathways that contributed to its rapid spread across the industry. Whole-genome sequencing was performed on 167C. jejuni ST-6964 isolates sampled from across 30 New Zealand commercial poultry enterprises. The genetic relatedness between isolates was determined using whole genome multilocus sequence typing (wgMLST). Permutational multivariate analysis of variance and distance-based linear models were used to explore the strength of the relationship between pairwise genetic associations among the C. jejuni isolates and each of several pairwise distance matrices, indicating either the geographical distance between farms or the network distance of transportation vehicles. Overall, a significant association was found between the pairwise genetic relatedness of the C. jejuni isolates and the parent company, the road distance and the network distance of transporting feed vehicles. This result suggests that the transportation of feed within the commercial poultry industry as well as other local contacts between flocks, such as the movements of personnel, may have played a significant role in the spread of C. jejuni. However, further information on the historical contact patterns between farms is needed to fully characterise the risk of these pathways and to understand how they could be targeted to reduce the spread of C. jejuni.
Description
Keywords
Campylobacter jejuni, Contact networks, Correlation matrices, PERMANOVA, Phylodynamics, Animals, Anti-Infective Agents, Campylobacter Infections, Campylobacter jejuni, Chickens, Genotype, New Zealand, Poultry
Citation
Greening SS, Zhang J, Midwinter AC, Wilkinson DA, Fayaz A, Williamson DA, Anderson MJ, Gates MC, French NP. (2021). Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand's commercial poultry network.. Epidemics. 37. (pp. 100521-).