Infrared Spectroscopy of Synovial Fluid Shows Accuracy as an Early Biomarker in an Equine Model of Traumatic Osteoarthritis

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dc.citation.issue7
dc.citation.volume14
dc.contributor.authorPanizzi L
dc.contributor.authorVignes M
dc.contributor.authorDittmer KE
dc.contributor.authorWaterland MR
dc.contributor.authorRogers CW
dc.contributor.authorSano H
dc.contributor.authorMcIlwraith CW
dc.contributor.authorRiley CB
dc.contributor.editorKaneps AJ
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-05-20T02:43:20Z
dc.date.available2024-05-20T02:43:20Z
dc.date.issued2024-03-22
dc.description.abstractOsteoarthritis is a leading cause of lameness and joint disease in horses. A simple, economical, and accurate diagnostic test is required for routine screening for OA. This study aimed to evaluate infrared (IR)-based synovial fluid biomarker profiling to detect early changes associated with a traumatically induced model of equine carpal osteoarthritis (OA). Unilateral carpal OA was induced arthroscopically in 9 of 17 healthy thoroughbred fillies; the remainder served as Sham-operated controls. The median age of both groups was 2 years. Synovial fluid (SF) was obtained before surgical induction of OA (Day 0) and weekly until Day 63. IR absorbance spectra were acquired from dried SF films. Following spectral pre-processing, predictive models using random forests were used to differentiate OA, Sham, and Control samples. The accuracy for distinguishing between OA and any other joint group was 80%. The classification accuracy by sampling day was 87%. For paired classification tasks, the accuracies by joint were 75% for OA vs. OA Control and 70% for OA vs. Sham. The accuracy for separating horses by group (OA vs. Sham) was 68%. In conclusion, SF IR spectroscopy accurately discriminates traumatically induced OA joints from controls.
dc.description.confidentialfalse
dc.edition.editionApril-1 2024
dc.format.pagination986-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38612225
dc.identifier.citationPanizzi L, Vignes M, Dittmer KE, Waterland MR, Rogers CW, Sano H, McIlwraith CW, Riley CB. (2024). Infrared Spectroscopy of Synovial Fluid Shows Accuracy as an Early Biomarker in an Equine Model of Traumatic Osteoarthritis.. Animals (Basel). 14. 7. (pp. 986-).
dc.identifier.doi10.3390/ani14070986
dc.identifier.eissn2076-2615
dc.identifier.elements-typejournal-article
dc.identifier.issn2076-2615
dc.identifier.number986
dc.identifier.piiani14070986
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69609
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2076-2615/14/7/986
dc.relation.isPartOfAnimals (Basel)
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbiomarker
dc.subjectcarpal
dc.subjectequine
dc.subjecthorse
dc.subjectinfrared
dc.subjectmodel
dc.subjectosteoarthritis
dc.subjectspectroscopy
dc.subjectsynovial fluid
dc.subjecttraumatic
dc.titleInfrared Spectroscopy of Synovial Fluid Shows Accuracy as an Early Biomarker in an Equine Model of Traumatic Osteoarthritis
dc.typeJournal article
pubs.elements-id488185
pubs.organisational-groupOther
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