Browsing by Author "Tan Y"

Now showing 1 - 4 of 4
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    Comparative transcriptomes reveal geographic differences in the ability of the liver of plateau zokors (Eospalax baileyi) to respond and adapt to toxic plants
    (BioMed Central Ltd, 2023-12) Tan Y; Wang Y; Liu Q; Wang Z; Shi S; Su J
    BACKGROUND: Environmental changes are expected to intensify in the future. The invasion of toxic plants under environmental changes may change herbivore feeding environments. Herbivores living long-term in toxic plant-feeding environments will inevitably ingest plant secondary metabolites (PSMs), and under different feeding environments are likely to have unique protection mechanisms that support improved adaptation to PSMs in their habitat. We aimed to compare different subterranean herbivore population responses and adaptations to toxic plants to unveil their feeding challenges. RESULTS: Here, we investigated the adaptive capacity of the liver in two geographically separated populations of plateau zokors (Eospalax baileyi) before and after exposure to the toxic plant Stellera chamaejasme (SC), at the organ, biochemical, and transcriptomic levels. The results showed no significant liver granules or inflammatory reactions in the Tianzhu (TZ) population after the SC treatment. The transaminase level in the TZ population was significantly lower than that in the Luqu population. Transcriptome analysis revealed that the TZ population exhibited interactions with other detoxification metabolic pathways by oxytocin pathway-associated genes, including diacylglycerol lipase alpha (Dagla), calcium/calmodulin dependent protein kinase II Alpha (Camk2a), and CD38 molecule (Cd38). The phase II process of liver drug metabolism increased to promote the rate of metabolism. We found that alternative splicing (AS) and the expression of the cyclin D (Ccnd1) gene interact-a TZ population hallmark-reduced liver inflammatory responses. CONCLUSION: Our study supports the detoxification limitation hypothesis that differences in liver detoxification metabolism gene expression and AS are potential factors in herbivore adaptation to PSMs and may be a strategy of different herbivore populations to improve toxic plant adaptability.
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    Himalayan Marmot (Marmota himalayana) Redistribution to High Latitudes under Climate Change
    (MDPI (Basel, Switzerland), 2023-08-28) Wang Z; Kang Y; Wang Y; Tan Y; Yao B; An K; Su J; Crowther M
    Climate warming and human activities impact the expansion and contraction of species distribution. The Himalayan marmot (Marmota himalayana) is a unique mammal and an ecosystem engineer in the Qinghai-Tibet Plateau (QTP). This pest aggravates grassland degradation and is a carrier and transmitter of plagues. Therefore, exploring the future distribution of Himalayan marmots based on climate change and human activities is crucial for ecosystem management, biodiversity conservation, and public health safety. Here, a maximum entropy model was explored to forecast changes in the distribution and centroid migration of the Himalayan marmot in the 2050s and 2070s. The results implied that the human footprint index (72.80%) and altitude (16.40%) were the crucial environmental factors affecting the potential distribution of Himalayan marmots, with moderately covered grassland being the preferred habitat of the Himalayan marmot. Over the next 30-50 years, the area of suitable habitat for the Himalayan marmot will increase slightly and the distribution center will shift towards higher latitudes in the northeastern part of the plateau. These results demonstrate the influence of climate change on Himalayan marmots and provide a theoretical reference for ecological management and plague monitoring.
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    Nanoengineered polymers and other organic materials in lung cancer treatment: Bridging the gap between research and clinical applications
    (Elsevier Ltd, 2024-03-25) Jin X; Heidari G; Hua Z; Lei Y; Huang J; Wu Z; Paiva-Santos AC; Guo Z; Karimi Male H; Neisiany RE; Sillanpää M; Prakash C; Wang X; Tan Y; Makvandi P; Xu Y
    Cancer remains a major global health challenge, with increasing incidence and mortality rates projected for the coming years. Lung cancer, in particular, poses significant obstacles due to late-stage diagnosis and limited treatment options. While advancements in molecular diagnostics have been made, there is a critical need to connect the dots between laboratory and hospital for better lung cancer treatment. Systemic therapy plays a crucial role in treating advanced-stage lung cancer, and recent efforts have focused on developing innovative drug delivery techniques. Nanoparticles (NPs) have emerged as a promising approach to lung cancer treatment, offering enhanced drug delivery, active targeting, and reduced toxicity. Organic-based nanomaterials, like polymeric nanoparticles, solid lipid nanoparticles, and liposomes hold great potential in this field. This review examines the application of NPs in lung cancer treatment, highlights current therapies, explores organic nanoparticle-based approaches, and discusses limitations and future perspectives in clinical translation.
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    Possibility of Wild Boar Harm Occurring in Five Provinces of Northwest China
    (MDPI (Basel, Switzerland), 2023-12-08) Liu P; Wang Z; An K; Tan Y; Ji W; Su J; Phillips CJC
    With the implementation of ecological engineering projects and related policies in China, wild boar (Sus scrofa) populations have surged, leading to increasingly serious conflicts with humans. We evaluated their potential habitat changes from the perspective of environmental suitability. To elucidate the suitable habitat characteristics for wild boars, we obtained data from 79 sites in five provinces in northwest China using database retrieval, human-wildlife conflict (HWC) incident questionnaires, and document retrieval. Thus, 10 environmental variables with lower correlation were selected, and potentially suitable distribution areas for wild boars under the current climate scenario were predicted based on the maximum entropy model. These areas were superimposed with different land use types in different periods to explore habitat selection. Precipitation seasonality (26.40%), human footprint index (16.50%), and elevation (11.90%) were the main environmental factors affecting wild boar distribution. The areas with high potential suitability for wild boars were mainly in the southeast and northwest of the region (total area of 2.63 × 105 km2). The land use types in the high-suitability zones are mainly woodland and grassland with high coverage, canopy density, and cultivated land borders. This study provides a reference for the effective prevention of HWC and management of wild boars.