Browsing by Author "Patel S"

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    Breaking paracyclophane: the unexpected formation of non-symmetric disubstituted nitro [2.2] metaparacyclophanes
    (Beilstein-Institut, 2021) Patel S; Dais TN; Plieger PG; Rowlands GJ
    Substituted [2.2]metaparacyclophanes are amongst the least studied of the simple cyclophanes. This is undoubtedly the result of the lengthy syntheses of these compounds. We report the simple synthesis of a rare example of a non-symmetric [2.2]metaparacyclophane. Treatment of [2.2]paracyclophane under standard nitration conditions gives a mixture of 4-nitro[2.2] paracyclophane, 4-hydroxy-5-nitro [2.2] metaparacyclophane and a cyclohexadienone cyclophane.
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    The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C-H activation
    (Royal Society of Chemistry, 2022-03-17) Tewari S; Mungalpara MN; Patel S; Rowlands GJ
    Planar chiral [2.2]paracyclophanes are resolved through the direct C-H arylation of enantiopure oxazolines, providing a convenient route to ligands and chiral materials. Preliminary results show that hydrolysis followed by decarboxylative phosphorylation leads to enantiopure [2.2]paracyclophane derivatives that are otherwise challenging to prepare.