Browsing by Author "Pain, SJ"

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    Does Viagra protect fetal lambs against maternal pregnancy toxaemia?
    (New Zealand Society of Animal Production, 2016) Peterson, SW; Pain, SJ; McCoard, SA; Oliver, M; Baker, PB; Kenyon, PR; Blair, HT
    Poor fetal growth is commonly caused by placental insufficiency. In sheep, multiple fetuses have relatively small placentae with fewer cotyledons than singletons, limiting blood flow to the placenta, especially in late gestation when fetal growth rate is highest. Factors that reduce fetal growth, such as maternal genotype, nutrition, age, parity, fetal number, or environmental temperature, typically reduce placental size and are associated with lower rates of fetal oxygen and nutrient uptakes and placental blood flow (Reynolds & Redmer 2001). Further, circumstances that influence placental vascular development have a dramatic impact on fetal growth and development, and affect neonatal survival and growth (Borowicz et al. 2007; Satterfield et al, 2010). Sildenafil citrate (SC, trade names Viagra or Avigra) increases vasodilatation of uteroplacental vessels (Wareing et al. 2005) and may represent a novel therapy to improve fetal lamb growth. Sildenafil citrate has successfully increased birth weight in rodent models and singleton bearing ewes (Satterfield et al. 2010; Miller at al. 2009). There is no published information regarding the use of SC in multiple-bearing ewes. The objective of this trial was to determine if SC administration to triplet-bearing ewes in late gestation could increase lamb birth weight. In addition, the influence of SC on the incidence of pregnancy toxaemia is also reported here.
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    Reproductive performance of singleton and twin female offspring born to ewe-lamb dams and mature adult dams
    (New Zealand Society of Animal Production, 7/07/2016) Loureiro, MFP; Kenyon, PR; Pain, SJ; Blair, HT
    This study was undertaken to compare the reproductive and live weight performance of female singleton and twin ewes born to either mature or young dams from 18 months to 2.5 years of age. One hundred and fifteen singleton- and twin-born female offspring born to either ewe-lamb (8 months at breeding) or adult ewe dams were maintained as one cohort under commercial New Zealand grazing conditions. Ewe live weights and body condition scores were recorded, as were ovulation rates at a synchronised breeding and number of fetuses present at pregnancy scanning. The live weight of ewes born to ewe-lambs were lighter (P<0.05) than those born to adult ewes at breeding and during their first pregnancy but not (P>0.05) at the weaning of their lambs. Twin-born ewes were lighter (P<0.05) than their singleton-born counterparts. There was no difference in corpora lutea number (P>0.05) at breeding or number of fetuses at pregnancy scanning. Lambs whose grand dam was a ewe-lamb were heavier at birth (P<0.05) but not at weaning (P>0.05) compared to those lambs whose grand dams was an adult ewe. This data suggests there are few negative impacts from selecting progeny born to ewe lambs as replacement ewes. However, before this hypothesis can be supported, lifetime data of these ewes needs to be collected.