Browsing by Author "Ma L"

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    Barriers and strategies for building information modelling implementation: a comparative study between New Zealand and China
    (1/01/2023) Ma L; Lovreglio R; Yi W; Yiu TW; Shan M
    Building Information Modelling (BIM) is a sharing platform that can present a parametric 3 D model with various project information in the form of a digital display. In recent years, BIM adoption has become increasing globally as the Architectural, Engineering, Construction (AEC) industry has recognised its benefits. Meanwhile, many challenges of BIM adoption in different countries have been well documented. To address the gap in literature, this study examines the differences and similarities of BIM adoption between New Zealand and China. A questionnaire was conducted across the two countries to investigate the barriers and strategies for the implementation of BIM. Data from 146 respondents was collected in New Zealand and China. The result shows that there is a difference in the perception of Knowledge Barrier, Technology Barrier, Internal Strategy and External Strategy (Legal/Technology viewpoint) between New Zealand professionals and Chinese professionals. The differences identified offer important implications for government agencies to promote BIM implementation and for BIM service providers to better target the end-users.
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    Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans
    (Hindawi, 2024-05-10) Xu Q; Gao H; Zhu F; Xu W; Wang Y; Xie J; Guo G; Yang L; Ma L; Shen Z; Li J; Regmi B
    Traditional Chinese medicine (TCM) serves as a significant adjunct to chemical treatment for chronic diseases. For instance, the administration of Baitouweng decoction (BTWD) has proven effective in the treatment of ulcerative colitis. However, the limited understanding of its pharmacokinetics (PK) has impeded its widespread use. Chinese Bama miniature pigs possess anatomical and physiological similarities to the human body, making them a valuable model for investigating PK properties. Consequently, the identification of PK properties in Bama miniature pigs can provide valuable insights for guiding the clinical application of BTWD in humans. To facilitate this research, a rapid and sensitive UPLC-MS/MS method has been developed for the simultaneous quantification of eleven active ingredients of BTWD in plasma. Chromatographic separation was conducted using an Acquity UPLC HSS T3 C18 column and a gradient mobile phase comprising acetonitrile and water (containing 0.1% acetic acid). The methodology was validated in accordance with the FDA Bioanalytical Method Validation Guidance for Industry. The lower limit of quantitation fell within the range of 0.60-2.01 ng/mL. Pharmacokinetic studies indicated that coptisine chloride, berberine, columbamine, phellodendrine, and obacunone exhibited low Cmax, while fraxetin, esculin, fraxin, and pulchinenoside B4 were rapidly absorbed and eliminated from the plasma. These findings have implications for the development of effective components in BTWD and the adjustment of clinical dosage regimens.